Endocrine Abstracts

Pseudohypoparathyroidism (PHP) is a group of rare hereditary diseases caused by tissue resistance to parathyroid hormone (PTH), there are two main types I and II. Type I is divided into subtypes. The authors present a case of PHP Ib, with hypocalcemia (level of total calcium 1.41 mmol/l), accidentally detected at childbirth. After the unsuccessful treatment of hypocalcemia, the etiology was considered, but the confirmation of the diagnosis were not adequately tightened. Due to...

Background: The aim of our study was to asses changes in the cross sectional area (CSA) of the median nerve by ultrasound in newly diagnosed acromegalic patients 1 year after treatment of acromegaly (transsphenoidal surgery, somatostatine analogues).Patients and methods: The study included 30 newly diagnosed acromegalic patients (18 females and 12 males) and 30 healthy controls (18 females and 12 males) matched for age, gender and body mass index. Clinic...

Introduction: Patients suffering from acromegaly, despite normal or even higher bone mineral density (BMD), have prevalent vertebral fractures (VFs). Impaired bone microarchitecture is involved fragility fracture development, but vitamin D status could be involved in this impairment.Aim of the study: Comparison of bone parameters such as BMD, trabecular bone score (TBS) and 3D-SHAPER parameters in acromegaly patients according to level of 25(OH)D3.<p...

Introduction: Acromegaly is associated with higher prevalence of vertebral fractures (VFx) and bone microarchitecture potentially play a role in fracture development. Trabecular bone score (TBS), a novel indicator of bone microstructure could provide additional information.Objectives: Assessment of BMD, TBS and bone turnover markers (BTM) in acromegaly patients in comparison to healthy controls with regard to gender, hypogonadism and disease activity.</p...

Combination of Turner syndrome (TS) and classical congenital adrenal hyperplasia (CAH) is rare worldwide. Incidence of CAH - autosomal recessive disorders characterized by enzyme defect of steroidogenic pathway, of which 90% ocuurs in the CYP21A2 gene coding 21-hydroxylase is 1:10000-16000. Incidencie of Turner syndrome is 1:2500 worldwide. Phenotypically, females with TS may present with a wide spectrum of clinical features. They may exhibit short stature, virilization, prema...